Top 5 Python Web Frameworks Developers Should Know in 2025

Smarter Choices for Building Scalable Web Apps

Summary: Heading towards 2026, Python continues to be a force to reckon with in web development. Being the easiest to learn, most readable, and feature-wise best ecosystem to do so, developers are working with Python frameworks and packages more than ever before to develop anything from mere APIs to full-scale enterprise platforms. But not all frameworks are the same, and the framework you do stick with will, therefore, affect your development speed, scale for the future, and maintainability of your code in your codebase. Here we will be talking about five of the rising Python web frameworks for 2025 worthy of watching. If you are an independent freelance developer, a first-time development team, or a new tech start-up, this article should have everything you need to make an informed decision about your next web development project.

Top 5 Python Web Frameworks Developers Should Know in 2025

Introduction:

There are so many frameworks out there. In fact, if you are using Python, it could be overwhelming thinking about which one to get started with: full-stack, micro, async-ready, modular, or somewhere in between. But the truth is: not every project is going to be built the same. This is exactly why getting to know the advantages of each Python web framework is so important in 2025.

Whether you are building a cool front-facing application or just designing the backend infrastructure, the framework you go with could save you months in development work. Again, this is a big part of why a top Python development company has a competitive advantage: they are able to select the right tool for the job.

In this blog, we will cover five of the best frameworks to work with Python web app development in 2025. These five frameworks are not just fads: they are used in the real world, are stable, and have active communities behind them. By the end of the blog, you will have an idea of the framework you would like to adopt as well as how to use it effectively.

1. FastAPI: The API Platform with Speed

FastAPI is not just called FastAPI; it is fast when it counts. FastAPI transitioned from introduction in 2018 to mainstream development at lightning speed because of its async architecture, its clean structure, and fantastic development capabilities.

So, while it should be no surprise in 2025, we’re really only going to highlight two reasons why FastAPI continues to stand out.

      Built for Speed: Utilizing Starlette and async Python, FastAPI provides performance to handle tens of thousands of connections simultaneously. FastAPI's performance is ideal for today's development environments, i.e., IoT back-ends involving microservices, real-time dashboards, etc.

      Neat Type Hints = Very Few Bugs: FastAPI utilizes Python type hints to automatically validate and throw run-time errors.

      Automatic Documentation: Built-in Swagger and ReDoc documentation is auto-generated and interactive, making it very quick to go from testing APIs to documenting handovers.

FastAPI is especially appealing for organizations providing Python web development services that prioritize speed, scalability, and clear communication of data.

2. Django: The Universal Workhorse that just won't die - and continues to improve!

Django is still going strong, and better! In 2025, Django 5.0 continues to be a proud member of the Python web framework community, equipped with some improved async support optimizations, better ORM query speeds, and enhanced project config capabilities. If you're in any development capacity and need to build easily scalable web platforms, Django is still the best framework for the job.

Here is why Django is still number one:

      Complete Toolbelt: Django comes complete with everything you need to get a robust web app up and running: ORM, templating engine, form handling, admin panel, etc. The aggregate of these items allows developers to focus on building instead of having to deal with obnoxious package installations.

      Robust built-in security: Because Django has a long list of built-in protections against common web threats, developers have the luxury of focusing on integrations and being less concerned about hardening their applications against threats.

      Comprehensive ecosystem: From Django REST Framework (DRF) to Celery, to channels for real-time interaction, and everything else, Django has it all. All of these are mature products, and there are tons of great resources in the wild for building production systems.

When you are in a top Python development company, Django is the framework you usually try to first branch out from. It's easy to get rolling if you are building software as a service (SaaS), or an MVP, or some other type of application; Django will just work.

3. Flask: The Adaptable Light Weight Veteran That Keeps Changing

Flask will survive and thrive in 2025. Flask is Ms. P for me. Flask's "do-it-your-way" approach appeals to developers who want control over every part of their application.

Reasons why Flask will continue to boom in 2025:

      Minimal Core = Max Freedom: Flask doesn't impose structure, so you can build your application however it makes sense to you.

      Extensible Ecosystem: Authentication? No problem! Caching? Where's a plug-in? Email? I've got a feeling they have one! If you want to roll your own solution to any of these aspects, you can roll your own solution!

      It is easy to learn: It is easy to use if you do not have a ton of experience with developing the backend, but also powerful for more advanced solutions.

Many teams, building custom Python web app solutions, would use Flask as the development framework simply because a full-stack framework would create unnecessary overhead for a simple custom solution.

4. Sanic: The Async-First Framework Built for Real-Time Performance

Sanic may not be vibrant, but Sanic is fast. Sanic was one of the first Python frameworks to leverage the async/await paradigm into its structure, and in 2025, Sanic was designed for developers who want speed and real-time capability built into the framework from the start.

Why Sanic is Different:

      Performance metrics: In the most recent benchmark tests, Sanic achieved approximately 110,000 requests per second on a clean testing machine that was only forwarding requests and with some sub-millisecond latencies.

      Real Time Capabilities: Sanic has native support for web-sockets, stream responses, and HTTP/2, so it is the best web framework to work with in regard to using streaming or real-time data.

      Granular middleware and routing: You can control every layer of your request/response runtime and optimize everything.

If you are in FinTech, gaming, or developing a traditionally highly interactive product, hiring Python developers with Sanic experience can have a serious impact on your performance.

5. Pyramid: The Quiet Leader for Complex Architectures

It is not widely used out there, like Django or FastAPI, but Pyramid's story is changing, and with the newly introduced plugin architecture that enables asynchronous integration and aspirations to promote maintainable components, Pyramid is seeing a resurgence in popularity with enterprise engineers in 2025.

When Pyramid is highly useful:

      Scale as you grow: You can start to build, then you can use Pyramid's modular approach to build a small application into a larger application or a multi-layered application.

      Customize: You can use your choice of template engine: Jinja2 or Chameleon.

      You can choose your DB: ORM with SQLAlchemy or NoSQL LM with MongoDB.

      Prime for the Enterprise: Pyramid is largely utilized for internal tools, CMS, and workflows when you want to hold accounts to smaller levels of detail.

If you are looking to find Python web development companies that can build scalable software operations for the years to come, Pyramid is certainly worth consideration as a viable framework option.

Final Take

The reality is that each of these Python frameworks has a sweet spot:

      Try FastAPI if you're working on an API that's designed to maximize speed, particularly if you're making an API for AI or microservices.

      Try Django if you're looking for a full-stack experience, loads of out-of-the-box helpers, and the strongest long-term backwards compatibility.

      Try Flask when you'd like to have the most flexibility and least "magic" or conventions.

      Utilize Sanic when building performance-critical real-time applications that require async all the way down.

      Utilize Pyramid when you are building something that is complex and large, and when you want 100% control over your project.

Regardless of what you are building, working with talented and experienced developers makes a world of difference. Whether you are looking for Python web development services or you are beginning to hire Python developers, your knowledge about these frameworks will enhance your collaboration and expectation management.

The top Python web development companies in 2025 do not simply use only one of these tools; they thoughtfully select and choose the tool that is right for the task at hand. Now you can too.

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